Guadalupe Burton

  • Utilizing this Discovery methodology, we identified a potential interaction amongst anandamide and gastric cancer, which was deeply buried in the huge quantities of available knowledge, and which has now been reliably confirmed by experimentation. In our examine, anandamide inhibited the proliferation of gastric cancer cells and mediated G2/M cell…[Read more]

  • The phosphorylation decreased the propensity of the location to fold into the helical conformation best for conversation with eIF4E, hence regulating the binding. Nonetheless, in the unbound sort in solution, the impact of phosphorylation on the secondary construction propensity of the largely disordered 4E-BP1 was little and comparable to what is…[Read more]

  • Guadalupe Burton posted an update 4 weeks ago

    Using this Discovery methodology, we identified a possible conversation between anandamide and gastric most cancers, which was deeply buried in the extensive amounts of accessible data, and which has now been reliably verified by experimentation. In our examine, anandamide inhibited the proliferation of gastric most cancers cells and mediated G2/M…[Read more]

  • At the same time, homologous recombination is generally as highthroughput- compatible as LIC. The modified primer design of the yeast-based DREAM mutagenesis method is simple and like the classic SDM covers all aspects of mutagenesis: mutation, insertion and deletion. The DREAM mutagenesis primer pair can easily be designed by the following basic…[Read more]

  • At the same time, homologous recombination is generally as highthroughput- compatible as LIC. The modified primer design of the yeast-based DREAM mutagenesis method is simple and like the classic SDM covers all aspects of mutagenesis: mutation, insertion and deletion. The DREAM mutagenesis primer pair can easily be designed by the following basic…[Read more]

  • Guadalupe Burton posted an update 2 months ago

    At the same time, homologous recombination is generally as highthroughput- compatible as LIC. The modified find for info primer design of the yeast-based DREAM mutagenesis method is simple and like the classic SDM covers all aspects of mutagenesis: mutation, insertion and deletion. The DREAM mutagenesis primer pair can easily be designed by the…[Read more]

  • Only by acute cigarette smoking or injecting nicotine can smokers reduce negative attentional bias and increase cortical arousal though the neurochemically ascending cholinergic and noradrenergic projection of nicotine. Cortical arousal may also involve neuronal activation through nicotinic cholinergic receptors or through the modulation of…[Read more]

  • Only by acute cigarette smoking or injecting nicotine can smokers reduce negative attentional bias and increase cortical arousal though the neurochemically ascending cholinergic and noradrenergic projection of nicotine. Cortical arousal may also involve neuronal activation through nicotinic cholinergic receptors or through the modulation of…[Read more]

  • Only by acute cigarette smoking or injecting nicotine can smokers reduce negative attentional bias and increase cortical arousal though the neurochemically ascending cholinergic and noradrenergic projection of nicotine. Cortical arousal may also involve neuronal activation through nicotinic cholinergic receptors or through the modulation of…[Read more]

  • Only by acute cigarette smoking or injecting nicotine can smokers reduce negative attentional bias and increase cortical arousal though the neurochemically ascending cholinergic and noradrenergic projection of nicotine. Cortical arousal may also involve neuronal activation through nicotinic cholinergic receptors or through the modulation of…[Read more]

  • Guadalupe Burton posted an update 3 months ago

    In our study, the positivity of S. pneumoniae by sputum culture was only 9%. Considering the low sensitivity of sputum culture, we included urinary antigen test-positive cases for the standard estimation and further included PCR-positive cases for the maximum estimation. The true value must lie between these values. The proportion of bacteremia…[Read more]

  • Guadalupe Burton posted an update 3 months ago

    The mule deer-derived brain fibroblast cell line has been used to demonstrate the anti-prion activity of pentosan polysulfate and a porphyrin compound. Besides the varying effectiveness of anti-prion compounds in different systems, another consideration for model development is the potential for significant effects of OTX015 co-infecting agents.…[Read more]

  • The mule deer-derived brain fibroblast cell line has been used to demonstrate the anti-prion activity of pentosan polysulfate and a porphyrin compound. Besides the varying effectiveness of anti-prion compounds in different systems, another consideration for model development is the potential for significant effects of co-infecting agents. It has…[Read more]

  • A PI induced accumulation of the CFTR precursor as observed in cultured human cells, was also observed with epoxomicin and MG-132 in our system. This may by itself not be sufficient for functional correction, but is likely show synergy with a suitable folding corrector and activator. Moreover, is seems likely that stabilisation of corrected human…[Read more]

  • A PI induced accumulation of the CFTR precursor as observed in cultured human cells, was also observed with epoxomicin and MG-132 in our system. This may by itself not be sufficient for functional correction, but is likely show synergy with a suitable folding corrector and activator. Moreover, is seems likely that stabilisation of corrected human…[Read more]

  • This study has revealed the IP inhibitor family as a promising anti-tubercular agent, targeting an essential component of the electron transport chain, QcrB. Due to the OTX015 nature of the target, it is conceivable that the IP compounds could target both active and latent phases of TB infection, an important requirement of future anti-tubercular…[Read more]

  • A PI induced accumulation of the CFTR precursor as observed in cultured human cells, was also observed with epoxomicin and MG-132 in our system. This may by itself not be sufficient for functional correction, but is likely show synergy with a suitable folding corrector and activator. Moreover, is seems likely that stabilisation of corrected human…[Read more]

  • Guadalupe Burton posted an update 4 months ago

    HD is a lethal autosomal dominant neurodegenerative disease caused by expansion of a stretch of CAG-encoded glutamines near the N-terminus of huntingtin, a protein whose mutant form accumulates as nuclear and cytoplasmic inclusions in the brain of HD patients. The disease is a progressive disorder with severe psychiatric, cognitive, and motor…[Read more]

  • However, it is not possible to assess the levels of both HMW- and LMW-AGEs using any of the current approaches. Subjecting foods to heating results in the formation of various AGE molecules, with the types of AGEs produced depending on the heat treatment method employed and the food involved. Unfortunately, most previous studies only examined the…[Read more]

  • However, it is not possible to assess the levels of both HMW- and LMW-AGEs using any of the current approaches. Subjecting foods to heating results in the formation of various AGE molecules, with the types of AGEs produced depending on the heat treatment method employed and the food involved. Unfortunately, most previous studies only examined the…[Read more]

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