Curley Nicolaisen

  • Curley Nicolaisen posted an update 5 days ago

    Injury to the cerebellum is becoming increasingly recognized in preterm infants. Also in animal models, reduced number of neurons in cerebellum has been reported in the postnatal guinea-pig and fetal sheep following intrauterine growthrestriction. Moreover, a recent study found a diffuse pattern of cerebellar white matter damage in animals exposed…[Read more]

  • Curley Nicolaisen posted an update 5 days ago

    Endometriosis is a complex gynecological disease which occurs in 10% of reproductive age women. The disease is characterized by the presence and growth of endometrial tissue outside the uterus, causing pelvic pain, and infertility. The pathogenesis of endometriosis is not clearly defined. However, the disease is thought to be principally caused by…[Read more]

  • The vulnerability of DKU80 strains to targeted double-strand breaks suggested we could perhaps rescue them through homologous recombination and, in the process, introduce desired point mutations. We observed that a 90 bp oligonucleotide homologous to the targeted region of PKG indeed improved the survival rate of DKU80 parasites transfected with…[Read more]

  • These observations can be compared with the results of a previous study in which we observed that intestinal morphological structures are also affected by CPF-exposure. We also found that CPF-exposure was associated with differences in protein expression in segments of the intestine. The immunohistochemical identification of claudin 4 seems to…[Read more]

  • Therefore, it is crucial to identify tumor molecular markers that are predictive of survival and metastasis and can identify ESCC patients who may benefit from surgical resection. Recently, several genes that are associated with ESCC metastasis have been identified, including Gadd45G, glioma-associated oncogene homolog 1, lysine-specific…[Read more]

  • These observations can be compared with the results of a previous study in which we observed that intestinal morphological structures are also affected by CPF-exposure. We also found that CPF-exposure was associated with differences in protein expression in segments of the intestine. The immunohistochemical identification of claudin 4 seems to…[Read more]

  • This was reflected by decreased islet numbers in GLP-1R KO mice and decreases in islet size and beta cell area together with increased alpha cell mass in both transgenic mouse models. Knock-out of GLP-1R also resulted in increased pancreatic GLP-1 without change of pancreatic glucagon or circulating hormone levels, suggesting that insulin…[Read more]

  • Curley Nicolaisen posted an update 2 weeks ago

    This lectin regulates cell-cell and cell-extracellular matrix interactions, cell signaling, inflammatory responses and biological events, such as cellular activation, migration, differentiation, apoptosis and tumor metastasis. Moreover, galectin-3 acts as a powerful pro-inflammatory molecule to myeloid cells by inducing chemotaxis of monocytes and…[Read more]

  • Curley Nicolaisen posted an update 2 weeks ago

    Therefore, it is crucial to identify tumor molecular markers that are predictive of survival and metastasis and can identify ESCC patients who may benefit from surgical resection. Recently, several genes that are associated with ESCC metastasis have been identified, including Gadd45G, glioma-associated oncogene homolog 1, lysine-specific…[Read more]

  • This lectin regulates cell-cell and cell-extracellular matrix interactions, cell signaling, inflammatory responses and biological events, such as cellular activation, migration, differentiation, apoptosis and tumor metastasis. Moreover, galectin-3 acts as a powerful pro-inflammatory molecule to myeloid cells by inducing chemotaxis of monocytes and…[Read more]

  • Curley Nicolaisen posted an update 1 month ago

    Both were subsequently found to be precursors of more potent inhibitors, analogues with various substituents on the triazole or imidazole rings, some with Ki values in the nM range, reviewed, amongst others, by Zien et al. and Battistutta et al.. Notwithstanding the high structural similarity between TBBt and TBBz, they differ significantly in…[Read more]

  • Curley Nicolaisen posted an update 1 month ago

    Gene expression profiling in human alcoholics and rodent models of binge drinking and dependence have provided insight into the changes in the brain transcriptional landscape resulting from different drinking paradigms; however, to date it is not clear whether transcriptome changes found in animal models of excessive alcohol consumption are…[Read more]

  • Curley Nicolaisen posted an update 1 month ago

    Previous reports of unmodified rhTIMP-1 pharmacokinetics in rodents have varied considerably; an early study found an elimination half-life of 4 h in mice, while another group recently reported a half-life of 42 h in an ischemia-reperfusion model in rats. Both of these values are considerably longer than the 1.1 h elimination half-life that we…[Read more]

  • Curley Nicolaisen posted an update 1 month ago

    In fact, detailed inspection of several conformational degrees of freedom for the protein showed that possible halogen bond-promoting conformations are not realized in the CK2a -TBBt complex, as illustrated by the His160 residue, for which a flip of the aromatic ring would have enabled interaction of Ne2 with a central halogen atom. The only…[Read more]

  • Gene expression profiling in human alcoholics and rodent models of binge drinking and dependence have provided insight into the changes in the brain transcriptional landscape resulting from different drinking paradigms; however, to date it is not clear whether transcriptome changes found in animal models of excessive alcohol consumption are…[Read more]

  • In fact, detailed inspection of several conformational degrees of freedom for the protein showed that possible halogen bond-promoting conformations are not realized in the CK2a -TBBt complex, as illustrated by the His160 residue, for which a flip of the aromatic ring would have enabled interaction of Ne2 with a central halogen atom. The only…[Read more]

  • In fact, detailed inspection of several conformational degrees of freedom for the protein showed that possible halogen bond-promoting conformations are not realized in the CK2a -TBBt complex, as illustrated by the His160 residue, for which a flip of the aromatic ring would have enabled interaction of Ne2 with a central halogen atom. The only…[Read more]

  • Gene expression profiling in human alcoholics and rodent models of binge drinking and dependence have provided insight into the changes in the brain transcriptional landscape resulting from different drinking paradigms; however, to date it is not clear whether transcriptome changes found in animal models of excessive alcohol consumption are…[Read more]

  • Both were subsequently found to be precursors of more potent inhibitors, analogues with various substituents on the triazole or imidazole rings, some with Ki values in the nM range, reviewed, amongst others, by Zien et al. and Battistutta et al.. Notwithstanding the high structural similarity between TBBt and TBBz, they differ significantly in…[Read more]

  • Our experiments demonstrate that LHX3 interacts with the acidic carboxyl CP-358774 domains of the TAF-1b and LANP INHAT components. It has been described that LANP and TAF-1b similarly interact with each other through their carboxyl terminal acidic domains. INHAT components have been described as both facilitating transcriptional repression and…[Read more]

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