Curley Nicolaisen

  • Curley Nicolaisen posted an update 4 weeks ago

    These experiments are carried out in the context of the MVB pathway and the operate of ESCRT equipment in MVBs is dominated by ubiquitin binding. Early reports determined a website link in between ubiquitin and retrovirus release and modern reports are unraveling much more about the position of ubiquitin in HIV-1 budding. In fact, ubiquitin…[Read more]

  • Comparable to their practical abilities in liver fibrosis, NK cells could also dampen fibrosis during the fibrotic period, by killing activated fibroblasts. As a result, the antifibrotic consequences linked with NK cells have the potential to influence the distinct pathophysiological phases of BIPF. NKT cells were described to defend towards…[Read more]

  • These experiments are performed in the context of the MVB pathway and the function of ESCRT equipment in MVBs is dominated by ubiquitin binding. Early studies identified a url between ubiquitin and retrovirus release and modern stories are unraveling a lot more about the part of ubiquitin in HIV-1 budding. Certainly, ubiquitin ligases have been…[Read more]

  • Similar to their functional abilities in liver fibrosis, NK cells might also dampen fibrosis during the fibrotic section, by killing activated fibroblasts. Thus, the antifibrotic results associated with NK cells have the capacity to affect the distinct pathophysiological phases of BIPF. NKT cells were noted to safeguard from fibrosis by releasing…[Read more]

  • Curley Nicolaisen posted an update 1 month ago

    Injury to the cerebellum is becoming increasingly recognized in preterm infants. Also in animal models, reduced number of neurons in cerebellum has been reported in the postnatal guinea-pig and fetal sheep following intrauterine growthrestriction. Moreover, a recent study found a diffuse pattern of cerebellar white matter damage in animals exposed…[Read more]

  • Curley Nicolaisen posted an update 1 month ago

    The first plasmid lacks a protospacer specific to the T. gondii genome, and the Cas9 nuclease has been replaced with a pyrimethamine resistance cassette. The second plasmid only differs from the pU6- SAG1 plasmid in that it lacks the protospacer. All DNA transfections decreased the viability of parasites, although this effect was smallest in…[Read more]

  • Curley Nicolaisen posted an update 1 month ago

    The vulnerability of DKU80 strains to targeted double-strand breaks suggested we could perhaps rescue them through homologous recombination and, in the process, introduce desired point mutations. We observed that a 90 bp oligonucleotide homologous to the targeted region of PKG indeed improved the survival rate of DKU80 parasites transfected with…[Read more]

  • The vulnerability of DKU80 strains to targeted double-strand breaks suggested we could perhaps rescue them through homologous recombination and, in the process, introduce desired point mutations. We observed that a 90 bp oligonucleotide homologous to the targeted region of PKG indeed improved the survival rate of DKU80 parasites transfected with…[Read more]

  • The vulnerability of DKU80 strains to targeted double-strand breaks suggested we could perhaps rescue them through homologous recombination and, in the process, introduce desired point mutations. We observed that a 90 bp oligonucleotide homologous to the targeted region of PKG indeed improved the survival rate of DKU80 parasites transfected with…[Read more]

  • Injury to the cerebellum is becoming increasingly recognized in preterm infants. Also in animal models, reduced number of neurons in cerebellum has been reported in the postnatal guinea-pig and fetal sheep following intrauterine growthrestriction. Moreover, a recent study found a diffuse pattern of cerebellar white matter damage in animals exposed…[Read more]

  • The first plasmid lacks a protospacer specific to the T. gondii genome, and the Cas9 nuclease has been replaced with a pyrimethamine resistance cassette. The second plasmid only differs from the pU6- SAG1 plasmid in that it lacks the protospacer. All DNA transfections decreased the viability of parasites, although this effect was smallest in…[Read more]

  • Curley Nicolaisen posted an update 2 months ago

    Injury to the cerebellum is becoming increasingly recognized in preterm infants. Also in animal models, reduced number of neurons in cerebellum has been reported in the postnatal guinea-pig and fetal sheep following intrauterine growthrestriction. Moreover, a recent study found a diffuse pattern of cerebellar white matter damage in animals exposed…[Read more]

  • Curley Nicolaisen posted an update 2 months ago

    Endometriosis is a complex gynecological disease which occurs in 10% of reproductive age women. The disease is characterized by the presence and growth of endometrial tissue outside the uterus, causing pelvic pain, and infertility. The pathogenesis of endometriosis is not clearly defined. However, the disease is thought to be principally caused by…[Read more]

  • Curley Nicolaisen posted an update 2 months ago

    The vulnerability of DKU80 strains to targeted double-strand breaks suggested we could perhaps rescue them through homologous recombination and, in the process, introduce desired point mutations. We observed that a 90 bp oligonucleotide homologous to the targeted region of PKG indeed improved the survival rate of DKU80 parasites transfected with…[Read more]

  • These observations can be compared with the results of a previous study in which we observed that intestinal morphological structures are also affected by CPF-exposure. We also found that CPF-exposure was associated with differences in protein expression in segments of the intestine. The immunohistochemical identification of claudin 4 seems to…[Read more]

  • Therefore, it is crucial to identify tumor molecular markers that are predictive of survival and metastasis and can identify ESCC patients who may benefit from surgical resection. Recently, several genes that are associated with ESCC metastasis have been identified, including Gadd45G, glioma-associated oncogene homolog 1, lysine-specific…[Read more]

  • These observations can be compared with the results of a previous study in which we observed that intestinal morphological structures are also affected by CPF-exposure. We also found that CPF-exposure was associated with differences in protein expression in segments of the intestine. The immunohistochemical identification of claudin 4 seems to…[Read more]

  • This was reflected by decreased islet numbers in GLP-1R KO mice and decreases in islet size and beta cell area together with increased alpha cell mass in both transgenic mouse models. Knock-out of GLP-1R also resulted in increased pancreatic GLP-1 without change of pancreatic glucagon or circulating hormone levels, suggesting that insulin…[Read more]

  • This lectin regulates cell-cell and cell-extracellular matrix interactions, cell signaling, inflammatory responses and biological events, such as cellular activation, migration, differentiation, apoptosis and tumor metastasis. Moreover, galectin-3 acts as a powerful pro-inflammatory molecule to myeloid cells by inducing chemotaxis of monocytes and…[Read more]

  • Therefore, it is crucial to identify tumor molecular markers that are predictive of survival and metastasis and can identify ESCC patients who may benefit from surgical resection. Recently, several genes that are associated with ESCC metastasis have been identified, including Gadd45G, glioma-associated oncogene homolog 1, lysine-specific…[Read more]

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